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14
Geneticdiseasesinartpaintings
In“TheAdorationofTheKings”(olionpanel,1564,NationalGallery,
London)paintedbyPieterBruegeltheElder,wecanseeBalthazar,theMoorish
king,standingontherightandCasperkneelingatthelowerleft(Fig.5).
Melchior,
tightly
holding
agoldenpotoffrankincense,
showsbilateralfacialdrooping,
partialptosisandpremature
frontalbalding,allthefeatures
ofmyotonicdystrophy[15].
Fig.5.“TheAdoration
ofTheKings”
(PieterBruegeltheElder,
oilonpanel,1564,
NationalGallery,London).
Melchior’sfacetaken
intheredcircle.
Paget’sdisease
Paget’sdisease,alsocalledosteitisdeformans,isadiseaseofunknown
etiology,butresearchershaveidentifiedagenethatcouldpossiblypredispose
tothedisease.ThefamilialclusteringofPaget’sdiseaseiswellrecognized,
aboutonethirdofthepatientsreporthavingafirst-degreerelativewith
thedisorder,
with
an
autosomal
dominant
pattern
of
inheritance.
FamilialPaget’sdiseasetendstooccurearlierinlifeandbemoreextensivethan
