Metastatic Disease in the Liver - Current Therapeutic Approaches

Andrzej Komorowski

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ISBN/ISSN:

978-83-200-6196-3

DOI:

Wydawnictwo:

PZWL Wydawnictwo Lekarskie

Rok wydania:

2020

Liczba stron:

211

XML:ISBN/ISSN:

ONIX MARC21

Bibliografia:

. Metastatic Disease in the Liver - Current Therapeutic Approaches. Red. Komorowski, Andrzej . : PZWL Wydawnictwo Lekarskie, 2020, 211 s. ISBN 978-83-200-6196-3

Bibliografia refWorks:

RT Book, Whole

SR Electronic(1)

A2 Komorowski, A.

T1 Metastatic Disease in the Liver - Current Therapeutic Approaches

PB PZWL Wydawnictwo Lekarskie

YR 2020

SN 978-83-200-6196-3

Bibliografia BibTex:

@Book{ 230500, author = "", editor = "Komorowski, Andrzej", title = "Metastatic Disease in the Liver - Current Therapeutic Approaches", publisher = "PZWL Wydawnictwo Lekarskie", year = "2020", address = "", isbn = "978-83-200-6196-3" }

Bibliografia endNote:

TY - BOOK

AU -

ED - Komorowski, Andrzej

TI - Metastatic Disease in the Liver - Current Therapeutic Approaches

PB - PZWL Wydawnictwo Lekarskie

CY -

PY - 2020

SN - 978-83-200-6196-3

ER -

Netografia (standard APA):

. Red. Komorowski, Andrzej. Metastatic Disease in the Liver - Current Therapeutic Approaches [baza danych online] : PZWL Wydawnictwo Lekarskie, 2020 [dostęp: 04 05 2024]. Dostęp w Ibuk Libra: https://libra.ibuk.pl/reader/metastatic-disease-in-the-liver---current-therapeutic-approaches-andrzej-komorowski-230500.

metastatic disease in the liver, modern management of liver tumours

EN Metastatic Disease in the Liver - Current Therapeutic Approaches offers a whole range of modern strategies for managing secondary liver malignancies. From diagnosis to non-operative strategies, with the emphasis on operative procedures, there a...

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ISBN/ISSN:

978-83-200-6196-3

DOI:

Wydawnictwo:

PZWL Wydawnictwo Lekarskie

Rok wydania:

2020

Liczba stron:

211

XML:ISBN/ISSN:

ONIX MARC21

1. Genetic profile of colorectal cancer liver metastases – Joanna Niemiec, Andrzej Jasiewicz, Barbara Niemiec, Artur Kowalik14
2. Liver imaging techniques – Tomasz Pawlik38
3. Strategies for colorectal cancer metastasis in the liver – Andrzej L. Komorowski46
4. Strategies for non-colorectal cancer metastasis in the liver – Piotr Kalinowski54
5. Metastatic colorectal cancer (mCRC) system therapy and management strategy – Aleksandra Grela-Wojewoda, Mirosława Püsküllüoğlu, Maksymilian Kruczała, Barbara Niemiec86
6. Open approach to liver tumours – Piotr Kalinowski100
7. ALPPS technique for the treatment of liver metastasis – Łukasz Masior, Michał Grąt114
8. Liver transplantation in the treatment of metastatic liver disease – Maciej Krasnodębski, Michał Grąt126
9. Laparoscopic approach to liver metastasis – Ruben Ciria, María Dolores Ayllón, Javier Briceño136
10. Thermal ablation for metastatic liver tumors – Jesse K. Sulzer, Patrick Salibi, David A. Ianniti152
11. Robotic approach to liver lesions – Marco V. Marino164
12. Novel training approaches to surgical management of liver lesions – Olexii Potapov, Andrzej L. Komorowski174
13. Major complications in the management of liver lesions – Andrii Lukashenko188
Index208

Geneticprofleofcolorectalcancerlivermetastases

fewgeneslowerstheconcordancebelow90%(50–80)andfnallysequencingof1000

genesinaseparatecohortcausedconcordancefalltoonlyabout5%betweenprimary

tumourandmetastases.

Thelowerreportedconcordancecouldbeattributabletointra-tumourheterogeneity

andresistanceofmetastasestothecytotoxicandbiologictreatment.Itwasadditionally

shownthat,metastasespossessgreaternumberofmutationsthenprimarytumour.

Ontheotherhand,applyingsensitivemethodscouldimproveconcordance.Thecon-

cordancestronglydependsonadequatesampleusedfortestingaswell.Theliverme-

tastasescouldbeeasilybiopsiedtocollectenoughmaterialformoleculardiagnostics

comparingtowithmetastasestothelungwhicharemorechallengingtosample.

Inconclusionthereishighconcordanceacrosstestedbiomarkersbetweenprimarytu-

moursandtheirlivermetastases,especiallyincaseofmarkerswithpredictivevalue

(KRAS,NRAS,BRAF).Theaboveresultsuggeststhatmoleculartestingcouldbedoneby

usingoneofthetwoabove-mentionedlocalizations[32].

1.2.

DISAGGREGATION,INVASIONANDINTRAVASA-

TIONOFMALIGNANTCELLS

Dissociationordisaggregationistheprocess,inwhichtumourcellsacquirediverse

alterationsingeneexpressionandthereforecellularfunctions,suchasadecreasein

epithelialmarkers(E-cadherin)andanincreaseinmesenchymalmarkers(N-cadherin,

vimentin,fbronectinetc.),whichiscalledepithelialtomesenchymaltransition(EMT).

Moreover,inthisprocessthecancercell,expandmigratoryandinvasivecapacities

andthereforedetachesfromtheprimarytumourandinvadesurroundingtissues[34,

35,36].

Duringthisphase,cancercellsinteractwithneighbouringstromalcells(fbroblasts,

macrophages15,lymphocytes,neutrophils,endothelialcells,dendriticcells,platelets),

extracellularmatrix(ECM)components(collagen,elastin,laminin,etc.),leadingto:

(1)neoangiogenesis16,(2)activationandproliferationofcancerassociatedfbroblasts17

15M1macrophages(CD11b+,CD80+,CD86+,CD204+,CD284+,CD14+,CD68+)

presentanti-tumouractivity,whileM2macrophages(TAM:tumour-associatedmacrophages;CD23+,

CD169+,CD206+,CD163+,CD14+,CD68+)aretumourgrowthfavouringonce,andareresponsiblefor:

immunosuppression,inactivationofTlymphocytes,tumourangiogenesis,productionofproteolyticenzymes

remodellingextracellularmatrix,stimulatingtomormotilityandproductionofgrowthfactors.

16Neoangiogenesisisswitchedonwhenoxygendiffusionfromthenormalcapillarynetworkis

unabletosupplytumourlargerthan1-2mm,thisprocessisrelatedtothebalancebetweenproangiogenic

factors:VEGF(Vascularendothelialgrowthfactor),PDGR(Platelet-derivedgrowthfactor),FGF(Fibroblastgrowth

factor),angiopoietin,etc;andanti-angiogenicfactors:endostatin,angiostatin,andTSP(Thrombospondins),etc.

17Earlyintumourogenesisfbroblastsinhibitearlystagesoftumourprogression[13,14].

duringcancergrowth,asaresultofmechanicaltension,fbroblastsacquirethemiyofbroblastphenotyoe,

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