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Geneticdiseasesinartpaintings
ForexamplethepaintingbytheaCarmelitemonkFilippodiTommaso
Lippi“MadonnadellaHumilita”(temperaonwood,1429-1432,Ambrosiana
Library&PictureGallery,Milan,Italy)showtherepresentationsofangels
withsomefacialcharacteristicsofbabieswithDownsyndrome(Fig.2).
ThereisahypothesissuggestingthattheDownsyndromefacialappearances
ofthese“babyangels”likelywasinfluencedbyLippi'searlyyears
inanorphanagewherehecouldhaveseenrejectedbabiesandinfants
withDownsyndrome[3,9,10].
Thechildina“MadonnaandChildwithSeraphinandCherubin”(tempera
onwood,1460,MetropolitanMuseumofArt,NewYork,USA)painting,
byafolloweroftheItalianartistAndreaMantegna,mighthavecretinism,
Downsyndromeorboth.AstheevidenceofDownsyndromewecouldlistslant
eyes,asmallnose,anopenmouthandadenoidalexpression.Aclearlyevident
additionalfeatureisthewidespacebetweenthe1stand2ndtoesoftheright
foot,but,thoughcommoninDownsyndrome,thefeatureisnotlimited
tothesyndrome[3].
